Article
A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism.
Journal of virology - 1 Jun 1993
Boyd M T, Simpson G R, Cann A J, Johnson M A, Weiss R A
Abstract excerpt
Specific point mutations which affect viral tropism have been identified in both the V3 loop and in the CD4-binding region of the human immunodeficiency virus type 1 surface glycoprotein gp120. Here we report that a single point mutation in the first variable region (V1) of human immunodeficiency...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- Cells, Cultured
- Genetic Variation
- HIV Envelope Protein gp120
- HIV-1
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Point Mutation
- T-Lymphocytes
- T-Lymphocytes, Regulatory