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Article

Strong link between the alpha 1-antitrypsin PiZ allele and Wegener's granulomatosis.

Journal of internal medicine - 1 Nov 1994

Elzouki A N, Segelmark M, Wieslander J, Eriksson S

Abstract excerpt

OBJECTIVES: To ascertain whether a relationship exists between the PiZ alpha 1-antitrypsin (alpha 1AT) variant and antineutrophil cytoplasm antibodies (ANCA)-positive vasculitis in a large group of Swedish patients, and whether analysis for the presence of the PiZ variant might be useful for diagnostic or prognostic purposes. DESIGN: Retrospective cross-sectional study. SETTING: The Department of Internal...

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Source

Identifiers

PMID: 7964431
DOI: 10.1111/j.1365-2796.1994.tb00842.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Strong link between the alpha 1-antitrypsin PiZ allele and Wegener's granulomatosis.PMID 7964431Read ↗

Alpha 1-antitrypsin phenotypes in patients with anti-neutrophil cytoplasmic antibody-positive vasculitis.Semantic proximity Read ↗

Complexes between proteinase 3, alpha 1-antitrypsin and proteinase 3 anti-neutrophil cytoplasm autoantibodies: a comparison between alpha 1-antitrypsin PiZ allele carriers and non-carriers with Wegener's granulomatosis.Semantic proximity Read ↗

alpha 1-Antitrypsin (AAT) deficiency and ANCA-positive systemic vasculitis: genetic and clinical implications.Semantic proximity Read ↗

Intestinal Wegener's granulomatosis in a patient with severe alpha-1-antitrypsin deficiency resulting from a unique combination of two deficiency alleles (PiZ and PiMProcida).Semantic proximity Read ↗

Incidence of alpha-1 antitrypsin Z and S alleles in patients with granulomatosis with polyangiitis--pilot study.Semantic proximity Read ↗

Increased PiZ gene frequency for alpha 1 antitrypsin in patients with genetic haemochromatosis.Semantic proximity Read ↗

The prevalence and clinical significance of alpha 1-antitrypsin deficiency (PiZ) and ANCA specificities (proteinase 3, BPI) in patients with ulcerative colitis.Semantic proximity Read ↗

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Genetic impact of pathogenesis and prognosis of ANCA-associated vasculitides.Semantic proximity Read ↗

Chronic liver disease in heterozygous alpha1-antitrypsin deficiency PiZ.Semantic proximity Read ↗

Analysis of anti-neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects.Semantic proximity Read ↗

Rapid and simple diagnosis of the two common alpha 1-proteinase inhibitor deficiency alleles Pi*Z and Pi*S by DNA analysis.Semantic proximity Read ↗

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