Strong link between the alpha 1-antitrypsin PiZ allele and Wegener's granulomatosis.

doi:10.1111/j.1365-2796.1994.tb00842.x

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Article

Strong link between the alpha 1-antitrypsin PiZ allele and Wegener's granulomatosis.

Journal of internal medicine - 1 Nov 1994

Elzouki A N, Segelmark M, Wieslander J, Eriksson S

Abstract excerpt

OBJECTIVES: To ascertain whether a relationship exists between the PiZ alpha 1-antitrypsin (alpha 1AT) variant and antineutrophil cytoplasm antibodies (ANCA)-positive vasculitis in a large group of Swedish patients, and whether analysis for the presence of the PiZ variant might be useful for diag...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
Biomarkers
Chi-Square Distribution
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Granulomatosis with Polyangiitis
Heterozygote
Humans
Male
Middle Aged
Retrospective Studies

Source

Open in PubMed

Identifiers

PMID: 7964431
DOI: 10.1111/j.1365-2796.1994.tb00842.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7964431-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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