Article
alpha 1-Antitrypsin (AAT) deficiency and ANCA-positive systemic vasculitis: genetic and clinical implications.
European journal of clinical investigation - 1 Aug 1997
Callea F, Gregorini G, Sinico A, Consalez G G, Gonzales G, Bossolasco M, Salvidio G, Radice A, Tira P, Candiano G, Rossi G, Petti A, Ravera G, Ghiggeri G, Gusmano R
Abstract excerpt
A high incidence of alpha 1-antitrypsin (AAT) deficiency has been reported in patients with C-ANCA systemic vasculitis in association with antibodies against proteinase-3 (PR3). To clarify the role of AAT deficiency in the acute vasculitic process as well as in progression of the disease, we studied 84 patients with either C-ANCA or P-ANCA vasculitis with special reference to: (a) the AAT gene, (b) the phenotypic...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Antineutrophil Cytoplasmic
- Autoantibodies
- Female
- Genotype
- Granulomatosis with Polyangiitis
- Humans
- Intracellular Signaling Peptides and Proteins
- Male
- Middle Aged
- Phenotype