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Article

A stable hammerhead structure is not required for endonucleolytic activity of a ribozyme in vivo.

Gene - 4 Nov 1994

Steinecke P, Steger G, Schreier P H

Abstract excerpt

Cleavage of a specific target, the mRNA encoding the bacterial neomycin phosphotransferase, by mutant satellite RNA of subterranean clover mottle virus (sSCMoV) ribozymes (Rz) was used to study the role of the hammerhead (Hh) structure in Rz activity in cis and in trans. The bimolecular Rz-target RNA interaction was predicted by computer secondary structure analysis. In vivo, endonucleolytic cleavage was...

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PMID: 7958987
DOI: 10.1016/0378-1119(94)90411-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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