Article
Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation.
Diabetes - 1 Dec 1994
Wajngot A, Alvarsson M, Glaser A, Efendic S, Luthman H, Grill V
Abstract excerpt
Insulin and glucagon release and insulin sensitivity were investigated in patients with glucokinase deficiency. Five subjects with a missense mutation (Glu256Lys) were studied. They were compared with six healthy subjects with low insulin response but normal glucose tolerance. Insulin and glucagon levels were measured at blood glucose 7.1 +/- 0.1 mmol/l and at 10.9 +/- 0.2 mmol/l with or without arginine (5 g...
Topics
- Adult
- Arginine
- Blood Glucose
- Drug Synergism
- Female
- Glucagon
- Glucokinase
- Glucose
- Glucose Tolerance Test
- Glutamic Acid
- Humans
- Insulin