Article
Induction of apoptosis by a dominant negative H-RAS mutant (116Y) in K562 cells.
Experimental cell research - 1 Nov 1994
Sakai N, Ogiso Y, Fujita H, Watari H, Koike T, Kuzumaki N
Abstract excerpt
Recent extensive work on apoptosis has begun to reveal its molecular mechanisms. Several genes that regulate apoptosis have been identified. Among them, the BCL2 gene is considered to be an important gene that inhibits apoptosis. However, there must be other genes, yet to be identified, which suppress apoptosis. It has been suggested that the activation of RAS function by BCR-ABL fusion protein in chronic...
Topics
- Apoptosis
- Base Sequence
- Cell Line
- Cell Survival
- DNA Damage
- DNA Primers
- DNA, Neoplasm
- Fusion Proteins, bcr-abl
- Gene Expression
- Genes, ras
- Humans
- Kinetics