Suppression of various human tumor cell lines by a dominant negative H-ras mutant.

Article

Suppression of various human tumor cell lines by a dominant negative H-ras mutant.

Gene therapy - 1 Nov 1994

Ogiso Y, Sakai N, Watari H, Yokoyama T, Kuzumaki N

Abstract excerpt

A dominant negative H-ras mutant, N116Y, was transfected into a variety of human tumor cell lines. N116Y extremely inhibited the proliferation of A431 (vulva), PC3 (prostate), T24 (bladder), MCF7 (breast), NKPS and TMK1 (stomach) cancer cell lines. A431 and PC3 cells were particularly susceptible...

Topics

Apoptosis
Base Sequence
Cell Division
DNA Primers
DNA, Neoplasm
Female
Gene Expression
Genes, Dominant
Genes, ras
Genetic Therapy
Genetic Vectors
Humans
Male
Molecular Sequence Data
Mutation
Neoplasms
Suppression, Genetic
Transfection

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