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Article

Microparticle drug sequestration provides a parallel pathway in the acquisition of cancer drug resistance.

European journal of pharmacology - 5 Dec 2013

Gong Joyce, Luk Frederick, Jaiswal Ritu, George Anthony M, Grau Georges Emile Raymond, Bebawy Mary

Abstract excerpt

Expanding on our previous findings demonstrating that microparticles (MPs) spread cancer multidrug resistance, we now show that MPs sequester drugs, reducing the free drug concentration available to cells. MPs were isolated from drug-sensitive and drug-resistant sub-clones of a human breast adenocarcinoma cell line and from human acute lymphoblastic leukemia cells. MPs were assessed for size, mitochondria, RNA...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24095666
DOI: 10.1016/j.ejphar.2013.09.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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