Article
HLA-B44-directed cytotoxic T cells associated with acute graft-versus-host disease following unrelated bone marrow transplantation.
Bone marrow transplantation - 1 Jul 1994
Keever C A, Leong N, Cunningham I, Copelan E A, Avalos B R, Klein J, Kapoor N, Adams P W, Orosz C G, Tutschka P J
Abstract excerpt
We describe the recipient of a marrow graft from an HLA-serologically identical unrelated donor from whom highly potent host-reactive CTL of donor origin were isolated in association with acute GVHD. Extensive sequence and biochemical analysis of the HLA complex of this donor and recipient reveal...
Topics
- Acute Disease
- Adult
- Alleles
- Base Sequence
- Bone Marrow Transplantation
- Cytotoxicity Tests, Immunologic
- DNA Primers
- Graft vs Host Disease
- HLA-B Antigens
- HLA-B44 Antigen
- Histocompatibility Testing
- Humans
- Leukemia, Myeloid, Accelerated Phase
- Male