Article
HLA-B44-directed cytotoxic T cells associated with acute graft-versus-host disease following unrelated bone marrow transplantation.
Bone marrow transplantation - 1 Jul 1994
Keever C A, Leong N, Cunningham I, Copelan E A, Avalos B R, Klein J, Kapoor N, Adams P W, Orosz C G, Tutschka P J
Abstract excerpt
We describe the recipient of a marrow graft from an HLA-serologically identical unrelated donor from whom highly potent host-reactive CTL of donor origin were isolated in association with acute GVHD. Extensive sequence and biochemical analysis of the HLA complex of this donor and recipient revealed several disparities in class I and class II HLA with the potential to be recognized by T cells from the donor or the...
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