Thiopurine methyltransferase activity in a French population: h.p.l.c. assay conditions and effects of drugs and inhibitors.

doi:10.1111/j.1365-2125.1994.tb04314.x

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Article

Thiopurine methyltransferase activity in a French population: h.p.l.c. assay conditions and effects of drugs and inhibitors.

British journal of clinical pharmacology - 1 Jul 1994

Jacqz-Aigrain E, Bessa E, Medard Y, Mircheva Y, Vilmer E

Abstract excerpt

1. Thiopurine methyltransferase (TPMT) is a cytosolic enzyme involved in the catabolism of thiopurine drugs, which are used to treat cancer patients and organ transplant recipients. Because TPMT activity is polymorphic and under genetic control, large interindividual variations in the immunosuppr...

Topics

Adult
Chromatography, High Pressure Liquid
Female
France
Gallic Acid
Humans
Male
Mercaptopurine
Methyltransferases
Phenotype
Polymorphism, Genetic

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