Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel variant of Sindbis virus is both neurovirulent and neuroinvasive in adult mice.

Archives of virology - 1 Jan 1992

Lustig S, Halevy M, Ben-Nathan D, Akov Y

Abstract excerpt

A strain of Sindbis virus (SV), recently isolated from mosquitoes in Israel, was used as a source for variants which differ in neuroinvasiveness and virulence that were generated by serial passage of SV in suckling and weanling mouse brain. At the 15th passage a neurovirulent variant was observed and designated SVN (neurovirulent). After 7 more passages in weanling mouse brains, another variant was observed and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Central Nervous System
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Israel

Share to Mice, Inbred BALB C

Share to Vero Cells

Share to Virulence

Source

Identifiers

PMID: 1346243
DOI: 10.1007/BF01317186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel variant of Sindbis virus is both neurovirulent and neuroinvasive in adult mice.PMID 1346243Read ↗

Genetic determinants of Sindbis virus neuroinvasivenessSemantic proximity Read ↗

Characterization of the Mouse Neuroinvasiveness of Selected European Strains of West Nile VirusSemantic proximity Read ↗

In vitro and in vivo characterization of a novel West Nile virus lineage 2 strainSemantic proximity Read ↗

La Crosse Virus Shows Strain-Specific Differences in PathogenesisSemantic proximity Read ↗

Differential Virulence and Pathogenesis of West Nile VirusesSemantic proximity Read ↗

Differential neurovirulence of Usutu virus lineages in mice and neuronal cellsSemantic proximity Read ↗

West Nile 25A virus infection of B-cell-deficient ((micro)MT) mice: characterization of neuroinvasiveness and pseudoreversion of the viral envelope protein.Semantic proximity Read ↗

Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype.Semantic proximity Read ↗

In Vitro and in Vivo Evaluation of Mutations in the NS Region of Lineage 2 West Nile Virus Associated with Neuroinvasiveness in a Mammalian Model.Semantic proximity Read ↗

Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus.Semantic proximity Read ↗

A BHK-21 cell culture-adapted tick-borne encephalitis virus mutant is attenuated for neuroinvasiveness.Semantic proximity Read ↗

West Nile virus envelope proteins: nucleotide sequence analysis of strains differing in mouse neuroinvasiveness.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.