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Article

A novel variant of Sindbis virus is both neurovirulent and neuroinvasive in adult mice.

Archives of virology - 1 Jan 1992

Lustig S, Halevy M, Ben-Nathan D, Akov Y

Abstract excerpt

A strain of Sindbis virus (SV), recently isolated from mosquitoes in Israel, was used as a source for variants which differ in neuroinvasiveness and virulence that were generated by serial passage of SV in suckling and weanling mouse brain. At the 15th passage a neurovirulent variant was observed and designated SVN (neurovirulent). After 7 more passages in weanling mouse brains, another variant was observed and...

Topics

Animals
Brain
Brain Diseases
Central Nervous System
Culicidae
Genetic Variation
Israel
Mice
Mice, Inbred BALB C
Serial Passage
Sindbis Virus
Vero Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viremia

Virulence

Source

Identifiers

PMID: 1346243
DOI: 10.1007/BF01317186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1346243-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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