Allele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians: lack of evidence for different allele frequencies in alcoholics.

doi:10.1111/j.1530-0277.1994.tb00905.x

Article

Allele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians: lack of evidence for different allele frequencies in alcoholics.

Alcoholism, clinical and experimental research - 1 Jun 1994

Chan R J, McBride A W, Thomasson H R, Ykenney A, Crabb D W

Abstract excerpt

Evidence from animal models and from recent reports on the efficacy of the opioid antagonist naltrexone in the treatment of alcoholism suggests that the endogenous opioid systems may play a role in alcohol seeking behavior. The gene encoding preproenkephalin A (PENK) is flanked at its 3' end by a polymorphic (CA)n repeat. We determined the allele frequencies for this locus in samples of Chinese and Atayal living...

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Allele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians: lack of evidence for different allele frequencies in alcoholics.

Abstract excerpt

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