Article
Evidence for a sustained genetic effect on fat storage capacity in cultured adipose cells from Zucker rats.
The American journal of physiology - 1 Sept 1994
Briquet-Laugier V, Dugail I, Ardouin B, Le Liepvre X, Lavau M, Quignard-Boulangé A
Abstract excerpt
Using mature adipocytes and preadipocytes from genetically obese Zucker rats, we investigated the cells' ability to maintain abnormal fat storage capacity when withdrawn from their in vivo environment. Long-term adipocyte cultures from obese rats displayed an increase in both glucose consumption (GC) and enzyme activities, including fatty acid synthase (4-fold), glycerol-3-phosphate dehydrogenase (4.5-fold),...
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