Article
Differential polypeptide expression in adipose tissue of lean and obese Zucker rats. Evidence of specifically repressed peptides in 7-day-old pre-obese rats.
The Biochemical journal - 15 Jun 1992
Laurent-Winter C, Dugail I, Quignard-Boulange A, Le Liepvre X, Lavau M
Abstract excerpt
Using two-dimensional electrophoresis on total extracts of adipose tissue from young lean (Fa/fa) and obese (fa/fa) Zucker rats, we have investigated the existence of early events at the protein level, before obvious obesity. Our results indicate that the two genotypes do not differ at 3 days of age in terms of polypeptide pattern. By 7 days of age, two polypeptides are transiently repressed in the fatty...
Topics
- Adipose Tissue
- Aging
- Animals
- Body Weight
- Electrophoresis, Gel, Two-Dimensional
- Female
- Genotype
- Heterozygote
- Male
- Obesity
- Peptide Biosynthesis