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Article

In vivo telomere dynamics of human hematopoietic stem cells

9 Dec 1997

Abstract excerpt

Aging in vivo and cell division in vitro are associated with telomere shortening. Several lines of evidence suggest that telomere length may be a good predictor of the long term replicative capacity of cells. To investigate the natural fate of chromosome telomeres of hematopoietic stem cells in vivo, we measured the telomere length of peripheral blood granulocytes from 11 fully engrafted bone marrow transplant...

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PMID: 9391104
DOI: 10.1073/pnas.94.25.13782

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