Article
Genetic instability in human ovarian cancer cell lines.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 1994
Orth K, Hung J, Gazdar A, Bowcock A, Mathis J M, Sambrook J
Abstract excerpt
We have analyzed the stability of microsatellites in cell lines derived from human ovarian cancers and found that 5 out of 10 of the ovarian tumor cell lines are genetically unstable at the majority of the loci analyzed. In clones and subclones derived serially from one of these cell lines (2774;...
Topics
- Adult
- Alleles
- Base Sequence
- Cell Line
- Chromosome Deletion
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Cystadenocarcinoma, Serous
- DNA Primers
- DNA Repair
- DNA, Neoplasm
- DNA-Binding Proteins
- Female
- Genetic Markers
- Humans
- Molecular Sequence Data
- MutS Homolog 2 Protein
- Ovarian Neoplasms
- Point Mutation