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Article

Genetic instability in human ovarian cancer cell lines.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 1994

Orth K, Hung J, Gazdar A, Bowcock A, Mathis J M, Sambrook J

Abstract excerpt

We have analyzed the stability of microsatellites in cell lines derived from human ovarian cancers and found that 5 out of 10 of the ovarian tumor cell lines are genetically unstable at the majority of the loci analyzed. In clones and subclones derived serially from one of these cell lines (2774; serous cystadenocarcinoma), a very high proportion of microsatellites distributed in many different regions of the...

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Identifiers

PMID: 7937795
DOI: 10.1073/pnas.91.20.9495
PMCID: PMC44839

Genes

MSH2

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