Article
Mutant isolation of mouse DNA topoisomerase II alpha in yeast.
Nucleic acids research - 11 Oct 1994
Adachi N, Ikeda H, Kikuchi A
Abstract excerpt
For characterizing in vivo functions of a mammalian protein, it is informative to obtain conditional mutations and apply them to the mouse genetic system. However, the isolation of conditional mutations has been quite difficult in cultured cells. We report here that functional expression of a heterologous mammalian gene in the yeast Saccharomyces cerevisiae provides a system for isolating mutated genes. We found...
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