Article
Complementation of a yeast top2ts mutation by a cDNA encoding rat DNA topoisomerase II alpha.
Molecular & general genetics : MGG - 27 Nov 1996
Yoon J H, Park S H, Cho H A, Seong R H, Hong S H, Park S D
Abstract excerpt
A series of yeast expression plasmids which comprise segments of the cDNA sequences encoding rat topo II alpha have been constructed. The transcription of these constructs is under the control of the yeast GAL1 promoter. Galactose-dependent expression of the cloned rat topo II alpha cDNA complemented a yeast top2ts mutation, as well as a deletion mutation at the yeast TOP2 locus. Truncation of 12 N-terminal amino...
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