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Article

Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase.

Molecular biology of the cell - 1 Jun 2008

Hutu Dana P, Guiard Bernard, Chacinska Agnieszka, Becker Dorothea, Pfanner Nikolaus, Rehling Peter, van der Laan Martin

Abstract excerpt

The presequence translocase of the mitochondrial inner membrane (TIM23 complex) mediates the import of preproteins with amino-terminal presequences. To drive matrix translocation the TIM23 complex recruits the presequence translocase-associated motor (PAM) with the matrix heat shock protein 70 (mtHsp70) as central subunit. Activity and localization of mtHsp70 are regulated by four membrane-associated...

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Identifiers

PMID: 18400944
DOI: 10.1091/mbc.e07-12-1226
PMCID: PMC2397324

Genes

PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase.PMID 18400944Read ↗

Pam17 and Tim44 act sequentially in protein import into the mitochondrial matrix.Semantic proximity Read ↗

Interaction of the J-protein heterodimer Pam18/Pam16 of the mitochondrial import motor with the translocon of the inner membrane.Semantic proximity Read ↗

Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.Semantic proximity Read ↗

Genetic analysis of complex interactions among components of the mitochondrial import motor and translocon in Saccharomyces cerevisiae.Semantic proximity Read ↗

The J-related segment of tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation.Semantic proximity Read ↗

Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane.Semantic proximity Read ↗

Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability.Semantic proximity Read ↗

Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane.Semantic proximity Read ↗

Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.Semantic proximity Read ↗

The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane.Semantic proximity Read ↗

Hotspots for Disease-Causing Mutations in the Mitochondrial TIM23 Import Complex.Semantic proximity Read ↗

Biogenesis of Tim Proteins of the Mitochondrial Carrier Import Pathway: Differential Targeting Mechanisms and Crossing Over with the Main Import PathwaySemantic proximity Read ↗

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