Article
Human follicle stimulating hormone receptor variants lacking transmembrane domains display altered post-translational conformations.
Molecular and cellular endocrinology - 25 Feb 2000
Peterson A J, Lindau-Shepard B, Brumberg H A, Dias J A
Abstract excerpt
Variant splicing of gonadotropin receptor mRNA commonly occurs, however expression of receptor protein variants and their trafficking has yet to be studied in detail. To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined....
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- CHO Cells
- Cricetinae
- Endoplasmic Reticulum
- Epitope Mapping
- Fluorescent Antibody Technique, Indirect
- Genetic Variation
- Humans
- Mice
- Molecular Sequence Data
- Protein Conformation
- Protein Isoforms