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Article

Differentiation and apoptosis of neuroblastoma cells: role of N-myc gene product.

Journal of cellular biochemistry - 1 Apr 1999

Galderisi U, Di Bernardo G, Cipollaro M, Peluso G, Cascino A, Cotrufo R, Melone M A

Abstract excerpt

To clarify the role and function of the N-myc product in cell differentiation and apoptosis, we used the antisense oligonucleotide technique to inhibit N-myc gene expression in neuroblastoma cells with different phenotypes: intermediate (I) and neuronal (N), or Schwann-glia (S), respectively. The results suggest that N-myc operates along different pathways. Inhibiting N-myc gene expression either results in...

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Share to Apoptosis
Share to Cell Division
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Nick-End Labeling

Share to Oligonucleotides, Antisense

Share to Proto-Oncogene Proteins c-myc

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10088728
DOI: 10.1002/(sici)1097-4644(19990401)73:1<97::aid-jcb11>3.0.co;2-m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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