Article
Genetic and molecular characterization of capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 3.
Molecular microbiology - 1 Jun 1994
Dillard J P, Yother J
Abstract excerpt
To achieve a better understanding of the genetics of capsular polysaccharide synthesis in Streptococcus pneumoniae, we have identified and characterized mutants deficient in type 3 capsule production. We identified a clone that restored encapsulation in one of our mutants and in a mutant deficient in UDP-glucose dehydrogenase. By hybridization, we developed a chromosomal map of the type 3-specific region and...
Topics
- Bacterial Capsules
- Chromosome Mapping
- Cloning, Molecular
- DNA, Bacterial
- Genes, Bacterial
- Genetic Linkage
- Genomic Library
- Mutagenesis, Insertional
- Mutation
- Streptococcus pneumoniae
- Transformation, Bacterial