Article
Recombinant expression of Streptococcus pneumoniae capsular polysaccharides in Escherichia coli.
Open biology - 1 Apr 2016
Kay Emily J, Yates Laura E, Terra Vanessa S, Cuccui Jon, Wren Brendan W
Abstract excerpt
Currently, Streptococcus pneumoniae is responsible for over 14 million cases of pneumonia worldwide annually, and over 1 million deaths, the majority of them children. The major determinant for pathogenesis is a polysaccharide capsule that is variable and is used to distinguish strains based on their serotype. The capsule forms the basis of the pneumococcal polysaccharide vaccine (PPV23) that contains purified...
Topics
- Bacterial Capsules
- Biosynthetic Pathways
- DNA Transposable Elements
- Enzyme-Linked Immunosorbent Assay
- Escherichia coli
- Fluorescent Antibody Technique
- Genes, Bacterial
- Genetic Loci
- Immunoblotting
- Lipopolysaccharides