Article
TAP2 gene polymorphism contributes to genetic susceptibility to multiple sclerosis.
Human immunology - 1 Mar 1995
Moins-Teisserenc H, Semana G, Alizadeh M, Loiseau P, Bobrynina V, Deschamps I, Edan G, Birebent B, Genetet B, Sabouraud O
Abstract excerpt
MS is an autoimmune demyelinating disease that has been known to be associated with the HLA-DRB1*1501-DQA1*0102-DQB1*0602 haplotype. TAP1 and TAP2, two genes encoded within the MHC class II region between HLA-DP and -DQ loci, display genetic variability and are involved in the transport of antigenic peptides from the cytoplasm to the endoplasmic reticulum. Comparison of 116 MS patients with Caucasoid controls did...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Amino Acid Sequence
- Base Sequence
- Genetic Predisposition to Disease
- HLA-D Antigens
- Humans
- Molecular Sequence Data