Article
Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant.
The Journal of biological chemistry - 28 Oct 1994
Benke D, Fritschy J M, Trzeciak A, Bannwarth W, Mohler H
Abstract excerpt
Native gamma-aminobutyric acid type A (GABAA) receptors containing different beta-subunit variants were identified immunobiochemically with antisera recognizing selectively the beta 1-, beta 2-, or beta 3-subunit. As determined by immunoprecipitation, the beta 2-subunit was present in 55-60% of G...
Topics
- Animals
- Brain Chemistry
- Carbolines
- Flumazenil
- Flunitrazepam
- Genetic Variation
- Immunohistochemistry
- Male
- Microscopy, Confocal
- Molecular Weight
- Precipitin Tests
- Protein Conformation
- Pyridazines
- Pyridines
- Rats
- Rats, Sprague-Dawley
- Receptors, GABA-A
- Tissue Distribution