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Article

Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.

European journal of pharmacology - 15 Feb 2002

Wingrove Peter B, Safo Patrick, Wheat Lola, Thompson Sally A, Wafford Keith A, Whiting Paul J

Abstract excerpt

Benzodiazepine pharmacology at the GABA(A) receptor is dependent on the alpha and gamma subunit isoforms present. Ligands with higher affinity for certain isoforms--selective compounds--have been classified into benzodiazepine type I and II and into diazepam-sensitive and diazepam-insensitive receptors. A single amino acid position (alpha1G201/alpha3E225) has been identified which discriminates BZI and BZII...

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Identifiers

PMID: 11864636
DOI: 10.1016/s0014-2999(02)01279-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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