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Article

Identification of amino acid residues that are crucial for FXIII-A intersubunit interactions and stability.

Blood - 9 Jan 2020

Li Bojun, Kohler Hans P, Schroeder Verena

Abstract excerpt

Coagulation factor XIII (FXIII) is the main stabilizer of the fibrin clot. It circulates in plasma as a tetramer of two A-subunits and two B-subunits. Under physiological conditions, FXIII-A exists as a dimer (FXIII-A2). The interactions between the FXIII-A-subunits that stabilize the FXIII-A2 dimer are not fully understood. We therefore designed a systematic approach to identify amino acid residues crucial for...

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Source

Identifiers

PMID: 31697820
DOI: 10.1182/blood.2019002127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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