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Article

Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity.

The Journal of biological chemistry - 26 Mar 2004

Wakabayashi Hironao, Freas Jan, Zhou Qian, Fay Philip J

Abstract excerpt

Generation of factor VIII cofactor activity requires divalent metal ions such as Ca2+ or Mn2+. Evaluation of cofactor reconstitution from isolated factor VIIIa subunits revealed the presence of a functional Ca2+ binding site within the A1 subunit. Isothermal titration calorimetry demonstrated at...

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PMID: 14722121
DOI: 10.1074/jbc.M311042200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14722121-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity.PMID 14722121Read ↗

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