Article
Degree of diversity of hepatitis C virus quasispecies and progression of liver disease.
Hepatology (Baltimore, Md.) - 1 Nov 1994
Honda M, Kaneko S, Sakai A, Unoura M, Murakami S, Kobayashi K
Abstract excerpt
We examined the quasispecies of the hepatitis C virus genome in 28 patients with liver disease of varying severity. Nucleotide sequences of the hepatitis C virus genome spanning the region from the core to envelope were used to calculate the nucleotide diversity: 0.58% +/- 0.88% in 5 patients with acute hepatitis, 0.85% +/- 0.62% in 5 patients with chronic persistent hepatitis, 1.79% +/- 0.92% in 11 patients with...
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