Article
APP+ T lymphocytes selectively sorted to endomysial tubes in polymyositis displace NCAM-expressing muscle fibers.
European journal of cell biology - 1 Dec 1993
Schubert W, Masters C L, Beyreuther K
Abstract excerpt
The characteristic pathogenic feature of polymyositis (PM) is muscle invasion by T lymphocytes penetrating the basal lamina and displacing the sarcolemma of normal muscle fibers (T cell invasion of endomysial tubes). Active forward movement of these T cells is indicated by cell extensions interdi...
Topics
- Amyloid beta-Protein Precursor
- CD4 Antigens
- CD8 Antigens
- Cell Adhesion Molecules, Neuronal
- Cell Movement
- Humans
- Immunohistochemistry
- Microscopy, Electron, Scanning
- Microscopy, Fluorescence
- Muscles
- Phenotype
- Polymyositis
- Sarcolemma
- T-Lymphocyte Subsets
- T-Lymphocytes