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Article

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

24 Oct 2002

Abstract excerpt

We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen. This approach resulted in the persistent clonal repopulation of T cells in those cancer patients, with the transferred cells proliferating in vivo, displaying functional activity,...

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Identifiers

PMID: 12242449
DOI: 10.1126/science.1076514

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