Article
Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation.
Cancer research - 1 Mar 2001
Kim J A, Averbook B J, Chambers K, Rothchild K, Kjaergaard J, Papay R, Shu S
Abstract excerpt
4-1BB is an inducible receptor-like protein expressed rapidly by both CD4 and CD8 T-cells after activation. 4-1BB cross-linking, either by binding to 4-1BBL or by antibody ligation, delivers a costimulatory signal to enhance T-cell activation and proliferation. Previous studies have demonstrated that the administration of 4-1BB monoclonal antibodies (mAbs) induces antitumor immune responses. In the current study...
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