Article
Oncogene expression in hepatic and biliary neoplasms of the fish Rivulus ocellatus marmoratus: correlation with histologic changes.
Carcinogenesis - 1 Sept 1994
Goodwin A E, Grizzle J M
Abstract excerpt
One day old mangrove rivulus (Rivulus ocellatus marmoratus) were exposed to 9 mg/l diethylnitrosamine (DEN) for 6 weeks, kept in water without DEN for an additional 18-20 months, then necropsied. Oncogene expression was detected by immunohistochemical staining of freeze-dried cryofixed livers. Positive controls for immunohistochemistry included tumors grown by injecting athymic nude mice with cell lines having...
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