Transcription-independent repair of nitrogen mustard-induced N-alkylpurines in the c-myc gene in Burkitt's lymphoma CA46 cells.

doi:10.1093/carcin/15.9.1779

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Article

Transcription-independent repair of nitrogen mustard-induced N-alkylpurines in the c-myc gene in Burkitt's lymphoma CA46 cells.

Carcinogenesis - 1 Sept 1994

Wassermann K, O'Connor P M, Jackman J, May A, Bohr V A

Abstract excerpt

Recently, it has been demonstrated that N-alkylpurines produced by nitrogen mustard are excised more rapidly from actively transcribing genes compared to non-coding regions of the overall genome. Such studies have suggested that transcriptional activity is a determinant of the rate of removal of...

Topics

Alkylation
Alleles
Burkitt Lymphoma
DNA Repair
DNA, Neoplasm
Genes, myc
Humans
Mechlorethamine
Purines
Transcription, Genetic
Translocation, Genetic
Tumor Cells, Cultured

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