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An In vitro Multistep Carcinogenesis Model for Human Cervical Cancer

15 Jul 2008

Abstract excerpt

Human papillomaviruses (HPV) are believed to be the primary causal agents for development of cervical cancer, and deregulated expression of two viral oncogenes E6 and E7 in basal cells, mostly by integration, is considered to be a critical event for disease progression. However, lines of evidence suggest that, besides expression of E6 and E7 genes, additional host genetic alterations are required for cancer...

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PMID: 18632622
DOI: 10.1158/0008-5472.can-07-6862

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