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Article

Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions.

Pharmacogenetics - 1 Jun 1994

Gaedigk A, Spielberg S P, Grant D M

Abstract excerpt

Therapy with the aromatic anticonvulsants phenytoin, phenobarbital and carbamazepine has been associated with the occurrence of rare idiosyncratic hypersensitivity reactions. These drugs are thought to be activated to potentially reactive arene oxide (epoxide) metabolites by cytochrome P450-dependent monooxygenation, while liver microsomal epoxide hydrolase (mEH) plays a detoxifying role by converting such...

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PMID: 7920694
DOI: 10.1097/00008571-199406000-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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