Article
Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions.
Pharmacogenetics - 1 Jun 1994
Gaedigk A, Spielberg S P, Grant D M
Abstract excerpt
Therapy with the aromatic anticonvulsants phenytoin, phenobarbital and carbamazepine has been associated with the occurrence of rare idiosyncratic hypersensitivity reactions. These drugs are thought to be activated to potentially reactive arene oxide (epoxide) metabolites by cytochrome P450-depen...
Topics
- Adult
- Anticonvulsants
- Base Sequence
- Child
- Child, Preschool
- DNA Primers
- DNA, Complementary
- Drug Hypersensitivity
- Epoxide Hydrolases
- Exons
- Female
- Genetic Variation
- Humans
- Introns
- Male
- Microsomes
- Middle Aged
- Molecular Sequence Data