Article
Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.
Biochemical pharmacology - 26 Oct 1995
Green V J, Pirmohamed M, Kitteringham N R, Gaedigk A, Grant D M, Boxer M, Burchell B, Park B K
Abstract excerpt
Carbamazepine therapy is occasionally complicated by hypersensitivity reactions, the mechanism of which is poorly understood. It has been suggested that affected individuals may have a genetically-determined defect of microsomal epoxide hydrolase. The aim of this study was to determine whether a single genetic mutation or pattern of mutations could be used to predict individual susceptibility to...
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