Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.

doi:10.1016/0006-2952(95)02009-8

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Article

Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.

Biochemical pharmacology - 26 Oct 1995

Green V J, Pirmohamed M, Kitteringham N R, Gaedigk A, Grant D M, Boxer M, Burchell B, Park B K

Abstract excerpt

Carbamazepine therapy is occasionally complicated by hypersensitivity reactions, the mechanism of which is poorly understood. It has been suggested that affected individuals may have a genetically-determined defect of microsomal epoxide hydrolase. The aim of this study was to determine whether a single genetic mutation or pattern of mutations could be used to predict individual susceptibility to...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Anticonvulsants
Carbamazepine
DNA
Disease Susceptibility
Drug Hypersensitivity
Epoxide Hydrolases
Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Humans

Male

Microsomes

Middle Aged

Mutation

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 7503783
DOI: 10.1016/0006-2952(95)02009-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7503783-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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