Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants.

doi:10.1093/hmg/3.3.421

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Article

Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants.

Human molecular genetics - 1 Mar 1994

Hassett C, Aicher L, Sidhu J S, Omiecinski C J

Abstract excerpt

Human microsomal epoxide hydrolase (mEH) is a biotransformation enzyme that metabolizes reactive epoxide intermediates to more water-soluble trans-dihydrodiol derivatives. We compared protein-coding sequences from six full-length human mEH DNA clones and assessed potential amino acid variation at...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Western
Cell Line
DNA
Epoxide Hydrolases
Genetic Variation
Genotype
Humans
Microsomes
Molecular Sequence Data
Mutagenesis, Site-Directed
Polymorphism, Genetic
RNA

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