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Article

Clinical aspects and biomarkers of Alzheimer's disease in Down syndrome.

Free radical biology & medicine - 1 Jan 2018

Zis Panagiotis, Strydom Andre

Abstract excerpt

Alzheimer's disease (AD) may affect in excess of 90% of individuals with Down syndrome (DS) after age 60, due to duplication of the APP gene in trisomy of chromosome 21, with neuropathology that is comparable to Sporadic AD and Familial AD (FAD). Previous literature suggested some unique features in clinical presentation of dementia in DS (DSd), which might be due to diagnostic difficulties, or represent a real...

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Source

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Identifiers

PMID: 28870521
DOI: 10.1016/j.freeradbiomed.2017.08.024
PMCID: PMC6451620

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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