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Article

Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome.

Neuroscience letters - 6 Apr 2001

Schupf N, Patel B, Silverman W, Zigman W B, Zhong N, Tycko B, Mehta P D, Mayeux R

Abstract excerpt

We compared levels of plasma amyloid beta-peptides Abeta1-42 and Abeta1-40 in 108 demented and nondemented adults with Down syndrome (DS) and 64 adults from the general population. Abeta1-42 and Abeta1-40 levels were significantly higher in adults with DS than in controls (P=0.0001). Compared to nondemented adults with DS, Abeta1-42 levels in demented adults with DS were selectively increased by 26% (28.2 pg/ml...

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Source

Identifiers

PMID: 11257432
DOI: 10.1016/s0304-3940(01)01657-3

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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