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Properties of tyrosine 766-->serine mutant of Escherichia coli DNA polymerase I: template-specific effects.

Biochemistry - 4 Oct 1994

Desai S D, Pandey V N, Modak M J

Abstract excerpt

In order to determine the role of Tyr 766 of Escherichia coli DNA polymerase I in the catalysis of DNA synthesis, we investigated the properties of a Tyr 766-->Ser (Y766S) mutant of the Klenow fragment of E. coli DNA polymerase I. We found that the rates of incorporation of only dTTP but not the other dNTP substrates were affected in the reactions catalyzed by the mutant enzyme, when homopolymeric...

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PMID: 7918405
DOI: 10.1021/bi00205a024

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ACACA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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