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Article

Occurrence of multiple JC virus variants with distinctive regulatory sequences in the brain of a single patient with progressive multifocal leukoencephalopathy.

Virus genes - 1 Mar 1994

Yogo Y, Guo J, Iida T, Satoh K, Taguchi F, Takahashi H, Hall W W, Nagashima K

Abstract excerpt

We established 99 JC virus (JCV) DNA clones directly from the brain of a single patient with progressive multifocal leukoencephalopathy (PML). Based upon restriction patterns, the cloned viral DNAs were classified into two major groups (NY-1A and -1B) containing 53 and 35 clones, respectively, an...

Topics

AIDS-Related Opportunistic Infections
Adult
Base Sequence
Brain
Capsid
Capsid Proteins
Cloning, Molecular
Genes, Viral
Genetic Variation
Humans
JC Virus
Leukoencephalopathy, Progressive Multifocal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Polymorphism, Restriction Fragment Length

Regulatory Sequences, Nucleic Acid

Restriction Mapping

Source

Identifiers

PMID: 7915447
DOI: 10.1007/BF01703608

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7915447-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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