Article
Sequential changes in the non-coding control region sequences of JC polyomaviruses from the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.
Archives of virology - 1 Mar 2013
Nakamichi Kazuo, Kishida Shuji, Tanaka Kozue, Suganuma Akihiko, Sano Yasuteru, Sano Hironori, Kanda Takashi, Maeda Norihisa, Kira Jun-Ichi, Itoh Ai, Kato Natsuko, Tomimoto Hidekazu, Kurane Ichiro, Lim Chang-Kweng, Mizusawa Hidehiro, Saijo Masayuki
Abstract excerpt
Progressive multifocal leukoencephalopathy (PML) is caused by JC polyomavirus (JCV) infection in the brain. JCV isolates from PML patients have variable mutations in the non-coding control region (NCCR) of the genome. This study was conducted to examine sequential changes in NCCR patterns of JCV isolates obtained from the cerebrospinal fluid (CSF) of PML patients. CSF specimens were collected from PML patients at...
Topics
- Adult
- Aged
- Base Sequence
- Brain
- DNA, Viral
- Female
- Genome, Viral
- Humans
- JC Virus
- Leukoencephalopathy, Progressive Multifocal