Article
JC virus regulatory region rearrangements in the brain of a long surviving patient with progressive multifocal leukoencephalopathy.
Journal of neurology, neurosurgery, and psychiatry - 1 Sept 2001
Yogo Y, Matsushima-Ohno T, Hayashi T, Sugimoto C, Sakurai M, Kanazawa I
Abstract excerpt
JC virus (JCV) infection of oligodendrocytes causes demyelination in brains of patients with with progressive multifocal leukoencephalopathy (PML). Expansion of demyelination throughout the brain is not fully understood. The opportunity was taken to investigate the postmortem brain of a long surviving patient with PML for whom diagnosis was made 4 years before death based on pathological and virological findings...
Topics
- Adult
- Autopsy
- Base Sequence
- Biopsy
- DNA, Viral
- Fatal Outcome
- Gene Duplication
- Gene Rearrangement
- Genetic Variation
- Humans
- In Situ Hybridization
- JC Virus
- Leukoencephalopathy, Progressive Multifocal