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Article

Origin of JC polyomavirus variants associated with progressive multifocal leukoencephalopathy.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1993

Iida T, Kitamura T, Guo J, Taguchi F, Aso Y, Nagashima K, Yogo Y

Abstract excerpt

JC polyomavirus (JCV) DNAs from the urine of nonimmunocompromised individuals (designated archetypal isolates) regularly contain a regulatory sequence that may have generated various regulatory sequences of JCV isolates derived from the brain of patients with progressive multifocal leukoencephalopathy (PML). In this report, we constructed a phylogenetic tree for 14 isolates (7 archetypes and 7 PML types) from DNA...

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Identifiers

PMID: 8389465
DOI: 10.1073/pnas.90.11.5062
PMCID: PMC46654

Genes

PML

Provenance

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Origin of JC polyomavirus variants associated with progressive multifocal leukoencephalopathy.PMID 8389465Read ↗

JC virus DNA is present in many human brain samples from patients without progressive multifocal leukoencephalopathySemantic proximity Read ↗

Occurrence of multiple JC virus variants with distinctive regulatory sequences in the brain of a single patient with progressive multifocal leukoencephalopathy.Semantic proximity Read ↗

JC virus regulatory region rearrangements and genotypes in progressive multifocal leukoencephalopathy: two independent aspects of virus variation.Semantic proximity Read ↗

New sequence polymorphisms in the outer loops of the JC polyomavirus major capsid protein (VP1) possibly associated with progressive multifocal leukoencephalopathySemantic proximity Read ↗

Human polyomavirus JC promoter/enhancer rearrangement patterns from progressive multifocal leukoencephalopathy brain are unique derivatives of a single archetypal structureSemantic proximity Read ↗

Isolation of a possible archetypal JC virus DNA sequence from nonimmunocompromised individualsSemantic proximity Read ↗

Genetic Diversity of the Polyomavirus JC and Implications for the Pathogenesis of Progressive Multifocal Leukoencephalopathy.Semantic proximity Read ↗

Functional comparison of PML-type and archetype strains of JC virus.Semantic proximity Read ↗

JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the hematogenous route.Semantic proximity Read ↗

Polyomavirus JC in the context of immunosuppression: a series of adaptive, DNA replication-driven recombination events in the development of progressive multifocal leukoencephalopathy.Semantic proximity Read ↗

Sequential changes in the non-coding control region sequences of JC polyomaviruses from the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.Semantic proximity Read ↗

Detection of archetype and rearranged variants of JC virus in multiple tissues from a pediatric PML patient.Semantic proximity Read ↗

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