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Article

Origin of JC polyomavirus variants associated with progressive multifocal leukoencephalopathy.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1993

Iida T, Kitamura T, Guo J, Taguchi F, Aso Y, Nagashima K, Yogo Y

Abstract excerpt

JC polyomavirus (JCV) DNAs from the urine of nonimmunocompromised individuals (designated archetypal isolates) regularly contain a regulatory sequence that may have generated various regulatory sequences of JCV isolates derived from the brain of patients with progressive multifocal leukoencephalo...

Topics

Base Sequence
Biological Evolution
Brain
Capsid
Capsid Proteins
Genes, Viral
Genetic Variation
Humans
JC Virus
Leukoencephalopathy, Progressive Multifocal
Molecular Sequence Data
Phylogeny

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Regulatory Sequences, Nucleic Acid

TATA Box

Urine

Viral Structural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8389465
DOI: 10.1073/pnas.90.11.5062
PMCID: PMC46654

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8389465-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Origin of JC polyomavirus variants associated with progressive multifocal leukoencephalopathy.PMID 8389465Read ↗

JC virus DNA is present in many human brain samples from patients without progressive multifocal leukoencephalopathySemantic proximity Read ↗

Occurrence of multiple JC virus variants with distinctive regulatory sequences in the brain of a single patient with progressive multifocal leukoencephalopathy.Semantic proximity Read ↗

JC virus regulatory region rearrangements and genotypes in progressive multifocal leukoencephalopathy: two independent aspects of virus variation.Semantic proximity Read ↗

New sequence polymorphisms in the outer loops of the JC polyomavirus major capsid protein (VP1) possibly associated with progressive multifocal leukoencephalopathySemantic proximity Read ↗

Human polyomavirus JC promoter/enhancer rearrangement patterns from progressive multifocal leukoencephalopathy brain are unique derivatives of a single archetypal structureSemantic proximity Read ↗

Isolation of a possible archetypal JC virus DNA sequence from nonimmunocompromised individualsSemantic proximity Read ↗

Genetic Diversity of the Polyomavirus JC and Implications for the Pathogenesis of Progressive Multifocal Leukoencephalopathy.Semantic proximity Read ↗

Functional comparison of PML-type and archetype strains of JC virus.Semantic proximity Read ↗

JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the hematogenous route.Semantic proximity Read ↗

Polyomavirus JC in the context of immunosuppression: a series of adaptive, DNA replication-driven recombination events in the development of progressive multifocal leukoencephalopathy.Semantic proximity Read ↗

Sequential changes in the non-coding control region sequences of JC polyomaviruses from the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.Semantic proximity Read ↗

Detection of archetype and rearranged variants of JC virus in multiple tissues from a pediatric PML patient.Semantic proximity Read ↗

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