Detection of reactivation and size variation in the regulatory region of JC virus in brain tissue.

doi:10.1136/jcp.46.7.646

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Article

Detection of reactivation and size variation in the regulatory region of JC virus in brain tissue.

Journal of clinical pathology - 1 Jul 1993

Mehal W Z, Esiri M M, Lo Y M, Chapman R W, Fleming K A

Abstract excerpt

AIMS: To develop a sensitive and specific polymerase chain reaction (PCR) based system for detecting genomic variation in JC virus. To apply this system to formalin fixed, paraffin wax embedded brain tissue from patients with and without progressive multifocal leucoencephalopathy (PML). METHODS:...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Brain
Female
Gene Amplification
Genes, Viral
Genetic Variation
Humans
JC Virus
Leukoencephalopathy, Progressive Multifocal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Polymerase Chain Reaction

Regulatory Sequences, Nucleic Acid

Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 8157753
DOI: 10.1136/jcp.46.7.646
PMCID: PMC501395

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8157753-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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