Anti-Ro(SSA) autoantibodies are associated with T cell receptor beta genes in systemic lupus erythematosus patients.

doi:10.1172/JCI114430

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Article

Anti-Ro(SSA) autoantibodies are associated with T cell receptor beta genes in systemic lupus erythematosus patients.

The Journal of clinical investigation - 1 Jan 1990

Frank M B, McArthur R, Harley J B, Fujisaku A

Abstract excerpt

Several of the heterogeneous clinical manifestations of systemic lupus erythematosus have been associated with specific autoantibodies. Associations between HLA class II antigens and autoantibodies to the ribonucleoproteins Ro(SSA) and La(SSB) have been reported in these patients. Because HLA class II molecules present antigen to T cell receptors (TCRs), we have searched for a TCR gene associated with the...

Topics

Adult
Alleles
Autoantibodies
Autoantigens
Cloning, Molecular
DNA Probes
Female
Genes
Humans
Leukocytes
Lupus Erythematosus, Systemic
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Polymorphism, Restriction Fragment Length

Precipitin Tests

RNA, Small Cytoplasmic

Receptors, Antigen, T-Cell

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 1967259
DOI: 10.1172/JCI114430
PMCID: PMC296383

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1967259-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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