Localization of the Br polymorphism on a 144 bp exon of the GPIa gene and its application in platelet DNA typing.

Article

Localization of the Br polymorphism on a 144 bp exon of the GPIa gene and its application in platelet DNA typing.

Thrombosis and haemostasis - 1 May 1994

Kalb R, Santoso S, Unkelbach K, Kiefel V, Mueller-Eckhardt C

Abstract excerpt

Alloimmunization against the human platelet alloantigen system Br (HPA-5) is the second most common cause of neonatal alloimmune thrombocytopenia (NAIT) in Caucasian populations. We have recently shown that a single base polymorphism at position 1648 on platelet mRNA coding for GPIa results in an...

Topics

Base Sequence
Exons
Genotype
Humans
Isoantigens
Molecular Sequence Data
Platelet Membrane Glycoproteins
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length

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