Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Localization of the Br polymorphism on a 144 bp exon of the GPIa gene and its application in platelet DNA typing.

Thrombosis and haemostasis - 1 May 1994

Kalb R, Santoso S, Unkelbach K, Kiefel V, Mueller-Eckhardt C

Abstract excerpt

Alloimmunization against the human platelet alloantigen system Br (HPA-5) is the second most common cause of neonatal alloimmune thrombocytopenia (NAIT) in Caucasian populations. We have recently shown that a single base polymorphism at position 1648 on platelet mRNA coding for GPIa results in an aminoacid substitution at position 505 on the mature GPIa which is associated with the two serological defined Br...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Exons
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Isoantigens

Share to Molecular Sequence Data

Share to Platelet Membrane Glycoproteins

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 7916494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Localization of the Br polymorphism on a 144 bp exon of the GPIa gene and its application in platelet DNA typing.PMID 7916494Read ↗

Genotyping of the platelet-specific alloantigen HPA-5 (Br(a)/Br(b)) using polymerase chain reaction with sequencespecific primers (PCR-SSP).Semantic proximity Read ↗

Systematic screening for genetic polymorphism in human platelet glycoprotein Ibalpha.Semantic proximity Read ↗

Molecular biology for platelet alloantigen typing.Semantic proximity Read ↗

NH2-terminal globular domain of human platelet glycoprotein Ib alpha has a methionine 145/threonine145 amino acid polymorphism, which is associated with the HPA-2 (Ko) alloantigens.Semantic proximity Read ↗

Association of a variable number of tandem repeats (VNTR) in glycoprotein Ib alpha and HPA-2 alloantigens.Semantic proximity Read ↗

Platelet and neutrophil alloantigen genotyping in clinical practice.Semantic proximity Read ↗

The human platelet alloantigens, HPA-5(a+, b-) and HPA-5(a-, b+), are associated with a Glu505/Lys505 polymorphism of glycoprotein Ia (the alpha 2 subunit of VLA-2).Semantic proximity Read ↗

Brb, a platelet alloantigen involved in neonatal alloimmune thrombocytopenia.Semantic proximity Read ↗

Non-radioactive SSCP for genotyping human platelet alloantigens.Semantic proximity Read ↗

New mutations on platelet GPIIb in Sub-Saharan African populations revealed by genotyping discrepancies.Semantic proximity Read ↗

Polymorphism of human platelet membrane glycoprotein IIb associated with the Baka/Bakb alloantigen systemSemantic proximity Read ↗

A third allele of the HPA-5 (Br) platelet alloantigen system identified in investigating a case of neonatal thrombocytopenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.