Article
Linkage disequilibrium patterns vary with chromosomal location: a case study from the von Willebrand factor region.
American journal of human genetics - 1 Aug 1994
Watkins W S, Zenger R, O'Brien E, Nyman D, Eriksson A W, Renlund M, Jorde L B
Abstract excerpt
Linkage disequilibrium analysis has been used as a tool for analyzing marker order and locating disease genes. Under appropriate circumstances, disequilibrium patterns reflect recombination events that have occurred throughout a population's history. As a result, disequilibrium mapping may be useful in genomic regions of < 1 cM where the number of informative meioses needed to detect recombinant individuals...
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