Article
Linkage disequilibrium patterns vary with chromosomal location: a case study from the von Willebrand factor region.
American journal of human genetics - 1 Aug 1994
Watkins W S, Zenger R, O'Brien E, Nyman D, Eriksson A W, Renlund M, Jorde L B
Abstract excerpt
Linkage disequilibrium analysis has been used as a tool for analyzing marker order and locating disease genes. Under appropriate circumstances, disequilibrium patterns reflect recombination events that have occurred throughout a population's history. As a result, disequilibrium mapping may be use...
Topics
- Alleles
- Base Sequence
- Cell Line
- Centromere
- Chi-Square Distribution
- Chromosome Mapping
- Chromosomes, Human, Pair 12
- DNA Primers
- Humans
- Likelihood Functions
- Linkage Disequilibrium
- Molecular Sequence Data
- Polymorphism, Restriction Fragment Length
- Regression Analysis