Article
Linkage disequilibrium between DNA markers at the low-density lipoprotein receptor gene.
Genetic epidemiology - 1 Jan 1990
Hegele R A, Plaetke R, Lalouel J M
Abstract excerpt
We determined pairwise linkage disequilibria between 12 restriction fragment length polymorphism (RFLP) markers at or near the low-density lipoprotein receptor (LDLR) locus on chromosome 19p13.2-13.1 in 92 unrelated individuals. Of these 12 RFLPs, two were newly identified under a cosmid-based strategy designed to screen for RFLPs. We estimated linkage disequilibrium by determining three different measurements: D...
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