Article
Linkage disequilibrium between DNA markers at the low-density lipoprotein receptor gene.
Genetic epidemiology - 1 Jan 1990
Hegele R A, Plaetke R, Lalouel J M
Abstract excerpt
We determined pairwise linkage disequilibria between 12 restriction fragment length polymorphism (RFLP) markers at or near the low-density lipoprotein receptor (LDLR) locus on chromosome 19p13.2-13.1 in 92 unrelated individuals. Of these 12 RFLPs, two were newly identified under a cosmid-based st...
Topics
- Alleles
- Blotting, Southern
- Chi-Square Distribution
- Chromosomes, Human, Pair 19
- Cosmids
- DNA
- DNA Probes
- Data Interpretation, Statistical
- Gene Frequency
- Genetic Markers
- Humans
- Linkage Disequilibrium
- Polymorphism, Restriction Fragment Length
- Receptors, LDL
- Restriction Mapping